Photoassisted access to enantiopure conformationally locked ribofuranosylamines spiro-linked to oxazolidino-diketopiperazines.
نویسندگان
چکیده
N-Furoylated L-threonine-, serine-, or cysteine-based aminoacetals are coupled with o-aminoketones or aldehydes to offer rapid access to diverse enantiopure polyheterocycles possessing conformationally locked aminoglycoside-containing molecular scaffolds. The key step involves photogeneration of azaxylylenes which undergo [4 + 4] or [4 + 2] cycloadditions to the tethered furoyl pendants.
منابع مشابه
Photoassisted synthesis of enantiopure alkaloid mimics possessing unprecedented polyheterocyclic cores.
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ورودعنوان ژورنال:
- ACS combinatorial science
دوره 15 1 شماره
صفحات -
تاریخ انتشار 2013